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Updated: Apr 23, 2026

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
Published on: May 15, 2013
[Dynamics of duration of tracheal forced expiratory noises during long-term isolation in the "Mars-500" experiment]
Abstract:
Dynamics of duration of tracheal forced expiratory noises in a group of volunteers was studied before, during and after 520-days confinement. The duration did not change in most volunteers. Two volunteers demonstrated significant changes of tracheal sounds duration and some spirometric parameters. Increase in duration of tracheal forced expiratory noises and decrease in spirometric parameters reveal ventilatory impairment of obstructive type. Analysis of duration of tracheal forced expiratory noises dynamics during prolonged confinement proves to be a sensitive technique to test ventilatory function changes.
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