Related Experiment Video
Updated: Apr 23, 2026
Controlled Cortical Impact Model for Traumatic Brain Injury
Published on: August 5, 2014
[Expression of CaMK II delta in cerebral cortex following traumatic brain injury]
Objective:
To observe the time-course expression of calcium-calmodulin dependent protein kinase II delta (CaMK II delta) in cerebral cortex after traumatic brain injury (TBI).
Methods:
The TBI rat model was established. The expression of CaMK II delta in cerebral cortex around injured area was tested by Western blotting and immunohistochemical staining.
Results:
Western blotting revealed expression of CaMK II delta in normal rat brain cortex. It gradually increased after TBI, peaked after 3 days, and then returned to normal level. The result of immunohistochemical staining was consistent with that of Western blotting.
Conclusion:
The expression of CaMK II delta around injured area after TBI increased initially and then decreased. It could be used as a new indicator for wound age determination following TBI.
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