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Clostridium difficile-associated typhlitis in specific pathogen free guineapigs in the absence of antimicrobial
R Boot1, A F Angulo, H C Walvoort
1Department of Animal Supply, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
Laboratory Animals
|July 1, 1989
Abstract:
Clostridium difficile (toxin) associated typhlitis was diagnosed in untreated barrier-maintained specific pathogen free guineapigs. It resembled the pathological lesions of antibiotic induced enterocolitis. The possible role of limited colonization resistance to C. difficile provided by mouse enteric microflora in the pathogenesis of the disease is discussed.