Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

26
Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show...
26
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

7.8K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
7.8K
Cross-bridge Cycle01:26

Cross-bridge Cycle

108.4K
As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
108.4K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

1.1K
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
1.1K
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

10
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and...
10
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

24
The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
24

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Walter Russell Brain (1895-1966).

Journal of neurology·2022
Same author

Pourfour du Petit (1664-1741).

Revue neurologique·2020
Same author

The "split brain" and Roger Wolcott Sperry (1913-1994).

Revue neurologique·2019
Same author

Early contribution of Alexandria medical school to the anatomy, physiology and pathology of the nervous system.

Revue neurologique·2018
Same author

Early Observations on Facial Palsy.

Journal of the history of the neurosciences·2014
Same author

Historical note on carotid disease and ligation.

European neurology·2014
Same journal

Preface.

Frontiers of neurology and neuroscience·2021
Same journal

Hypocretin/Orexin, Sleep and Alzheimer's Disease.

Frontiers of neurology and neuroscience·2021
Same journal

Sleep and Metabolism: Implication of Lateral Hypothalamic Neurons.

Frontiers of neurology and neuroscience·2021
Same journal

The Insomnia-Addiction Positive Feedback Loop: Role of the Orexin System.

Frontiers of neurology and neuroscience·2021
Same journal

Heterogeneity of Hypocretin/Orexin Neurons.

Frontiers of neurology and neuroscience·2021
Same journal

Hypocretin/Orexin Receptor Pharmacology and Sleep Phases.

Frontiers of neurology and neuroscience·2021
See all related articles

Related Experiment Video

Updated: Apr 23, 2026

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons
07:43

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons

Published on: January 7, 2019

6.4K

Before Charcot.

J M S Pearce1

  • 1Department of Neurology, Hull Royal Infirmary, Hull, UK.

Frontiers of Neurology and Neuroscience
|October 3, 2014
PubMed
Summary
This summary is machine-generated.

Hysteria

More Related Videos

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
06:35

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration

Published on: June 15, 2018

22.7K
Author Spotlight: Unveiling Mitochondrial Contact Sites and Architectural Insights
07:55

Author Spotlight: Unveiling Mitochondrial Contact Sites and Architectural Insights

Published on: June 16, 2023

2.3K

Related Experiment Videos

Last Updated: Apr 23, 2026

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons
07:43

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons

Published on: January 7, 2019

6.4K
In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
06:35

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration

Published on: June 15, 2018

22.7K
Author Spotlight: Unveiling Mitochondrial Contact Sites and Architectural Insights
07:55

Author Spotlight: Unveiling Mitochondrial Contact Sites and Architectural Insights

Published on: June 16, 2023

2.3K

Area of Science:

  • Neurology
  • History of Medicine

Background:

  • Hysteria has a long history of controversy since Greco-Roman Medicine.
  • Lack of objective signs fueled diverse, often conflicting, theories.
  • Theories were influenced by social, cultural, and gender factors.

Observation:

  • Charcot investigated hysteria to find neurological explanations.
  • He studied patients with hysteria, epilepsy, and other nervous disorders.
  • His work built upon centuries of prior medical thought.

Findings:

  • Charcot aimed to identify neurological abnormalities in hysterics.
  • His research was influenced by predecessors like Sydenham and Briquet.
  • Charcot's work gained international recognition at Salpêtrière.

Implications:

  • Charcot's investigations contributed to understanding neurological disorders.
  • His efforts advanced the scientific study of hysteria.
  • The historical context highlights the evolution of medical diagnosis.