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Updated: Apr 23, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
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Synovial sarcoma of the ethmoidal sinus.

H-T Wong1, C-Y Ho2, A R Nazarina2

  • 1Department of Otorhinolaryngology,University of Malaya,Kuala Lumpur,Malaysia.

The Journal of Laryngology and Otology
|October 3, 2014
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Summary

This case report details a rare instance of ethmoidal sinus synovial sarcoma in an elderly patient. Early diagnosis and surgical removal are crucial, though the prognosis for this aggressive cancer remains poor.

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Area of Science:

  • Oncology
  • Head and Neck Surgery
  • Pathology

Background:

  • Synovial sarcoma is a rare, high-grade soft tissue malignancy.
  • It predominantly affects extremities, with head and neck involvement being uncommon (less than 10%).
  • Ethmoidal sinus localization of synovial sarcoma is exceptionally rare.

Observation:

  • An 80-year-old female presented with right epistaxis.
  • Nasal endoscopy and biopsy confirmed synovial sarcoma.
  • The patient underwent endoscopic tumor excision.

Findings:

  • Synovial sarcoma of the ethmoidal sinus is an extremely rare diagnosis.
  • Surgical excision followed by radiotherapy is the recommended treatment.
  • Despite treatment, the prognosis is generally poor, with a high mortality rate within a year.

Implications:

  • Highlights the importance of considering rare diagnoses in head and neck oncology.
  • Emphasizes the need for multidisciplinary management of ethmoidal sinus malignancies.
  • Underscores the poor prognosis associated with advanced synovial sarcoma, necessitating further research into novel therapeutic strategies.