Related Experiment Video
Updated: Apr 23, 2026
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Evaluation of circulating YKL-40 levels in idiopathic interstitial pneumonias
Nicoline M Korthagen1, Coline H M van Moorsel, Pieter Zanen
1Center of Interstitial Lung Diseases, Department of Pulmonology, St. Antonius Hospital, PO Box 2500, 3430 EM, Nieuwegein, The Netherlands.
Introduction:
YKL-40 is a novel biomarker in diseases with inflammation, fibrosis and tissue remodelling. Previously, circulating YKL-40 was shown to be elevated in patients with idiopathic pulmonary fibrosis (IPF) and was associated with survival.
Objective:
To compare YKL-40 serum levels between IPF and other interstitial pneumonias such as non-specific interstitial pneumonia (NSIP), smoking-related interstitial lung disease (SR-ILD) and cryptogenic organising pneumonia (COP).
Materials And Methods:
Serum YKL-40 levels were measured in 124 healthy controls and 315 patients. Serial measurements were available in 36 patients with IPF and 6 patients with COP.
Results:
Serum YKL-40 levels were elevated in all patient groups compared to controls (p < 0.0001), and highest levels were found in the most fibrotic diseases, which showed worst prognosis.
Conclusion:
YKL-40 is highly elevated in fibrotic interstitial pneumonias and may reflect the degree of activity of the fibrogenic process. Remarkably, levels remain high in IPF, but can decrease in other interstitial pneumonias, which appears to be related to a better prognosis.
