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Platelet and other hemostatic characteristics in patients with chronic urticaria

Nilgun Isiksacan1, Murat Koser2, Ferhan Cemsitoglu3

  • 1Central Laboratory, Dr Sadi Konuk Training and Research Hospital, Bakirkoy, Istanbul, Turkey.

Angiology
|October 3, 2014
PubMed

Insights

Platelet aggregation was reduced in chronic urticaria (CU) patients, with elevated D-dimer levels indicating activated coagulation and fibrinolysis. These findings suggest platelets play a role in CU development.

Area of Science:

  • Immunology
  • Hematology
  • Dermatology

Background:

  • Coagulation and fibrinolysis are implicated in chronic urticaria (CU).
  • The specific role of platelets in CU pathogenesis requires further elucidation.

Purpose of the Study:

  • To assess platelet aggregation in patients with CU.
  • To evaluate coagulation and fibrinolysis parameters in CU patients.

Main Methods:

  • Platelet aggregation was measured using an impedance aggregometer with various agonists (ADP, arachidonic acid, TRAP, ristocetin).
  • Coagulation and fibrinolysis markers, including D-dimer and mean platelet volume, were analyzed.
  • 34 CU patients and 36 healthy controls were included.

Main Results:

  • Patients with CU showed significantly decreased platelet aggregation in response to ristocetin and thrombin receptor-activating peptide (TRAP).
  • Elevated D-dimer levels and decreased mean platelet volume were observed in CU patients.
  • No significant alterations were found in other coagulation assays.

Conclusions:

  • Activated coagulation and fibrinolysis are indicated in CU patients by elevated D-dimer levels.
  • Altered platelet function, specifically reduced aggregation, may contribute to the pathogenesis of chronic urticaria.
  • Further evaluation of platelet function could clarify their role in CU.

Keywords:
D-dimeraggregationchronic urticariacoagulationplatelet

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