Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

649
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
649
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

2.2K
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
2.2K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

634
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
634
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

476
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
476
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

653
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
653

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

19(S)-Hydroxyeicosatetraenoic Acid Promotes Airway Smooth Muscle Relaxation and Decreases DNA Synthesis Through the Prostacyclin Receptor.

American journal of respiratory cell and molecular biology·2026
Same author

Seeing Clearly: Blinded and Unblinded Evidence for Symptom Benefit After Chronic Total Occlusion Percutaneous Coronary Intervention.

Journal of the American College of Cardiology·2026
Same author

Selective Activation of the Tryptophan-Kynurenine Pathway in Fontan Circulation.

Pediatric cardiology·2026
Same author

Paclitaxel-Coated Balloon Versus Uncoated Balloon for Coronary In-Stent Restenosis: Two-Year Follow-Up of the AGENT-IDE Randomized Clinical Trial.

Circulation·2026
Same author

Plasma Lipidomics Identify Pathways Linked to Acute Lung Injury in a Porcine One-Lung Ventilation Surgery Model.

International journal of molecular sciences·2026
Same author

Oxidized Phosphatidylcholines Inhibit Airway Smooth Muscle β2-Adrenergic Receptors via Protein Kinase C.

American journal of respiratory cell and molecular biology·2026

Related Experiment Video

Updated: Apr 23, 2026

A Rat Carotid Artery Pressure-Controlled Segmental Balloon Injury with Periadventitial Therapeutic Application
06:53

A Rat Carotid Artery Pressure-Controlled Segmental Balloon Injury with Periadventitial Therapeutic Application

Published on: July 9, 2020

4.6K

Subintimal space plaque modification for "balloon-uncrossable" chronic total occlusions.

Minh N Vo1, Amir Ravandi, J Aaron Grantham

  • 1University of Manitoba, 409 Tache Ave, Winnipeg, Manitoba R2H 2A6, Canada. mvo@sbgh.mb.ca.

The Journal of Invasive Cardiology
|October 3, 2014
PubMed
Summary

Novel techniques use the subintimal space to cross complex coronary lesions. Antegrade and retrograde dissection reentry enables treatment of balloon-uncrossable lesions.

More Related Videos

Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model
12:00

Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model

Published on: November 24, 2014

19.0K
The Rabbit Model of Accelerated Atherosclerosis: A Methodological Perspective of the Iliac Artery Balloon Injury
09:14

The Rabbit Model of Accelerated Atherosclerosis: A Methodological Perspective of the Iliac Artery Balloon Injury

Published on: October 3, 2017

11.7K

Related Experiment Videos

Last Updated: Apr 23, 2026

A Rat Carotid Artery Pressure-Controlled Segmental Balloon Injury with Periadventitial Therapeutic Application
06:53

A Rat Carotid Artery Pressure-Controlled Segmental Balloon Injury with Periadventitial Therapeutic Application

Published on: July 9, 2020

4.6K
Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model
12:00

Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model

Published on: November 24, 2014

19.0K
The Rabbit Model of Accelerated Atherosclerosis: A Methodological Perspective of the Iliac Artery Balloon Injury
09:14

The Rabbit Model of Accelerated Atherosclerosis: A Methodological Perspective of the Iliac Artery Balloon Injury

Published on: October 3, 2017

11.7K

Area of Science:

  • Interventional Cardiology
  • Vascular Biology

Background:

  • Percutaneous coronary intervention (PCI) for chronic total occlusions (CTO) remains challenging.
  • Subintimal techniques offer a pathway for lesion traversal when conventional methods fail.

Observation:

  • Novel techniques leverage the subintimal space for safe and efficient crossing of occluded coronary segments.
  • Antegrade and retrograde dissection reentry (ARDR) is an increasingly utilized method for CTO crossing.

Findings:

  • This study introduces "subintimal space plaque modification" using ARDR techniques.
  • This approach effectively treats coronary lesions that are "balloon-uncrossable" by conventional means.

Implications:

  • Subintimal space plaque modification expands treatment options for complex coronary artery disease.
  • ARDR techniques enhance the success rates of PCI in challenging CTO cases.