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A spectrum project: preterm birth and small-for-gestational age among infants with birth defects

F Miquel-Verges1, B S Mosley2, A S Block2

  • 1Neonatology Section, College of Medicine, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, AR, USA.

Journal of Perinatology : Official Journal of the California Perinatal Association
|October 3, 2014
PubMed

Insights

Infants with birth defects (BDs) are more likely to be born prematurely and small-for-gestational age (SGA). This highlights a complex interplay between fetal development, prematurity, and growth.

Area of Science:

  • Perinatal epidemiology
  • Developmental biology
  • Public health

Background:

  • Birth defects (BDs) are a significant concern in infant health.
  • Prematurity and small-for-gestational age (SGA) are known risk factors for adverse infant outcomes.
  • Understanding the relationship between BDs and these conditions is crucial for prevention and intervention.

Purpose of the Study:

  • To investigate the association between birth defects (BDs), prematurity, and small-for-gestational age (SGA).
  • To analyze these associations in a large, population-based sample of live births.

Main Methods:

  • Utilized data from the National Birth Defects Prevention Study.
  • Included 18,737 infants with BDs and 7,999 control infants.
  • Employed logistic regression models, adjusting for relevant covariates.

Main Results:

  • Infants with BDs were significantly more likely to be born prematurely compared to controls.
  • Highest odds ratios for preterm birth were observed for specific BDs like intestinal atresia and gastroschisis.
  • A higher proportion of infants with BDs were small-for-gestational age (SGA) than controls (17.2% vs. 7.8%).

Conclusions:

  • Infants with birth defects exhibit a higher likelihood of prematurity and SGA.
  • Findings support a complex interaction between BD development, premature birth, and intrauterine growth.
  • This research provides further evidence for the interconnectedness of these critical developmental factors.
Abstract

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