Related Experiment Video
Updated: Apr 23, 2026

Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses
Published on: March 29, 2017
[Signaling mechanisms involved in resolution of inflammation]
Rodolfo Daniel Cervantes-Villagrana1, Alberto Rafael Cervantes-Villagrana2, José Miguel Presno-Bernal3
1Departamento de Investigación Clínica, Grupo Diagnóstico Médico Proa, México, D.F.
Abstract:
Inflammation is a physiological process, which eliminates pathogens and induces repair of damaged tissue. This process is controlled by negative feedback mechanisms, but if the inflammation persists, it generates a deleterious autoimmune process or can to contribute with diseases such as obesity or cancer. The inflammation resolution involves mechanisms such as decrease of proliferation and maturation of immune cells, phagocytosis and apoptosis of immune cells, and decrease of proinflammatory mediators. Therefore, is relevant to study the physiological effects of specific receptors that participate in inflammation resolution and the design of specific agonists as conventional anti-inflammatory therapeutics, without dramatic collateral effects. In this review, we study some mechanisms associated with inflammation inhibition, particularly the transduction of receptors for ligands with anti-inflammatory effects and that are relevant for their potential therapeutic.
Related Concept Videos
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Acute Inflammation I: Inflammatory Response
Acute Inflammation I: Cellular Phase
Acute Inflammation II: Local and Systemic Effects
Inflammatory Response I: Vascular and Cellular
Inflammation

