Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Membrane Fluidity01:26

Membrane Fluidity

13.8K
Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is...
13.8K
Membrane Fluidity01:23

Membrane Fluidity

149.7K
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
149.7K
Comparing Intermolecular Forces: Melting Point, Boiling Point, and Miscibility02:34

Comparing Intermolecular Forces: Melting Point, Boiling Point, and Miscibility

42.5K
Intermolecular forces are attractive forces that exist between molecules. They dictate several bulk properties, such as melting points, boiling points, and solubilities (miscibilities) of substances. Molar mass, molecular shape, and polarity affect the strength of different intermolecular forces, which influence the magnitude of physical properties across a family of molecules.
Temporary attractive forces like dispersion are present in all molecules, whether they are polar or nonpolar. They...
42.5K
Molecular Shape and Polarity03:37

Molecular Shape and Polarity

52.8K
Dipole Moment of a Molecule
52.8K
Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

7.9K
Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
7.9K
Fluid Mosaic Model01:19

Fluid Mosaic Model

14.4K
Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich...
14.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From Atomic Interactions to Molecular Miscibility and Philicity: Deciphering Enthalpic Driving Forces.

The journal of physical chemistry. A·2026
Same author

Bridging Atomistic and Mesoscale Lithium Transport via Machine-Learned Force Fields and Markov State Models.

Journal of chemical theory and computation·2026
Same author

Molecular Origins of Philicity: How Atomic Interactions Determine Miscibility and Diffusivity.

Chemphyschem : a European journal of chemical physics and physical chemistry·2026
Same author

Efficient Calculation of Electrostatic Energies for Large-Scale Nonadiabatic Molecular Dynamics in a Site Basis.

Journal of chemical theory and computation·2025
Same author

Representative Random Sampling of Chemical Space.

Journal of chemical theory and computation·2025
Same author

Intrinsic dimensionality of molecular properties.

The Journal of chemical physics·2025

Related Experiment Video

Updated: Apr 23, 2026

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

3.3K

Perfluoroalkane force field for lipid membrane environments.

Guido Falk von Rudorff1, Tobias Watermann, Daniel Sebastiani

  • 1Dahlem Center for Complex Quantum Systems, Freie Universität Berlin , Arnimallee 14, 14195 Berlin, Germany.

The Journal of Physical Chemistry. B
|October 3, 2014
PubMed
Summary
This summary is machine-generated.

We developed new atomic parameters for perfluoroalkanes for CHARMM force field simulations. These parameters enable accurate modeling of perfluoroalkanes

More Related Videos

Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers
10:15

Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers

Published on: July 22, 2015

14.4K
A New Straightforward Method for Lipophilicity logP Measurement using 19F NMR Spectroscopy
09:32

A New Straightforward Method for Lipophilicity logP Measurement using 19F NMR Spectroscopy

Published on: January 30, 2019

13.8K

Related Experiment Videos

Last Updated: Apr 23, 2026

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

3.3K
Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers
10:15

Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers

Published on: July 22, 2015

14.4K
A New Straightforward Method for Lipophilicity logP Measurement using 19F NMR Spectroscopy
09:32

A New Straightforward Method for Lipophilicity logP Measurement using 19F NMR Spectroscopy

Published on: January 30, 2019

13.8K

Area of Science:

  • Computational chemistry and molecular modeling.
  • Materials science and biochemistry.

Background:

  • Perfluorinated alkanes possess unique philicity, distinct from hydrophobicity or lipophilicity.
  • Their distinct properties enable diverse applications in materials science and biochemistry.

Purpose of the Study:

  • To develop accurate atomic parameters for perfluoroalkanes within the CHARMM force field.
  • To enable robust simulations of perfluoroalkanes in various chemical and biological systems.

Main Methods:

  • Parametrization of bonded and nonbonded interactions following CHARMM and CGenFF force field conventions.
  • Focus on van der Waals parameters, fitted to experimental densities across a range of temperatures and pressures.

Main Results:

  • Comprehensive atomic parameters for perfluoroalkanes suitable for CHARMM simulations.
  • Accurate reproduction of experimental densities for perfluoroalkanes.

Conclusions:

  • The new parameters facilitate simulations of biologically relevant systems, including transmembrane molecules and their effects on membrane properties.
  • This work expands the applicability of the CHARMM force field to systems containing perfluorinated alkanes.