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Animal models of exfoliation syndrome, now and future
Simon W M John1, Jeffrey M Harder, John H Fingert
1*The Howard Hughes Medical Institute †The Jackson Laboratory, Bar Harbor, ME ‡Department of Ophthalmology, Tufts University School of Medicine, Boston, MA Departments of §Ophthalmology and Visual Sciences ∥Molecular Physiology and Biophysics, University of Iowa ¶Center for the Prevention and Treatment of Visual Loss, Iowa City VA Health Care System, Iowa City, IA.
Abstract:
At present, no animal models fully embody exfoliation syndrome or exfoliation glaucoma. Both genetic and environmental factors appear critical for disease manifestation, and both must be considered when generating animal models. Because mice provide a powerful mammalian platform for modeling complex disease, this paper focuses on mouse models of exfoliation syndrome and exfoliation glaucoma.
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