[Preliminary study of two inbred mice models for infection and immunity of Brucellosis]

We established 2 animal models of Brucellosis using inbred mice (BALB/c and C57/BL) infected with virulent strains of B. melitensis 16, B. abortus 544 and B. suis 12 followed by bacteriological, serological, cellular immunological as well as histopathological examinations. It was shown that the BALB/c was more sensitive than C57/BL to brucella infection, especially to B. abortus 544. It is suggested that BALB/c infected with 544A might be the experimental animal of choice for studying chronic brucella infection. Studies on PFC kinetics of murine Brucellosis were undertaken. It was found that there were varying degrees of immunosuppression of PFC formation in the infectious process of three species of brucella, particularly in B. melitensis 16 M infection. We also observed the allergic reaction of the infected mice to intracutaneous administration of brucellin and found that the C57/BL was more sensitive than BALB/c. It was shown that there was an immunosuppression period between the 37th approximately 45th days after infection in C57/BL. The above mentioned findings provide elementary data for study on the role of immunosuppression in the pathogenesis of Brucellosis. It also provides some basic data for the study of experimental brucella infection in inbred mice.