Renal effects of atrial natriuretic factor (99-126) in water-deprived sheep

1. The renal response to renal arterial infusion of synthetic human atrial natriuretic factor (ANF) (99-126) at 50 micrograms/h was examined in conscious sheep dehydrated by 48 h water deprivation and was compared with the response of normally hydrated animals. 2. Renal arterial infusion of ANF produced increases in the excretion of Na, K, Ca and urine in both dehydrated and normally hydrated animals, although the effect was significantly blunted in dehydrated animals compared with normally hydrated animals. 3. The attenuation of renal effects of ANF in dehydrated animals is probably due to the negative sodium and/or fluid balance of the dehydrated animals.