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Effect of vitamin D3 on mild to moderate persistent asthmatic patients: A randomized controlled pilot study

A D Nageswari1, M G Rajanandh2, R Kamala Priyanka3

  • 1Department of Pulmonary Medicine, SRM Medical College Hospital and Research Centre, Porur, India.

Perspectives in Clinical Research
|October 3, 2014
PubMed
Abstract

Insights

Vitamin D3 supplementation shows promise as an effective adjunctive therapy for asthma patients, improving lung function. Further research is needed to confirm these findings over longer periods.

Area of Science:

  • Pulmonology
  • Clinical Nutrition
  • Pharmacology

Background:

  • Asthma is a prevalent chronic airway inflammatory condition with limited treatment options.
  • The precise role of vitamin D3 in asthma management remains unclear.
  • Investigating novel therapeutic avenues is crucial for improving patient outcomes.

Purpose of the Study:

  • To evaluate the efficacy of vitamin D3 supplementation in patients with mild to moderate persistent asthma.
  • To assess the impact of vitamin D3 as an add-on therapy to standard asthma medications.

Main Methods:

  • An open-label, randomized comparative trial involving 48 asthma patients over 90 days.
  • Patients received either usual care (budesonide and formoterol) or usual care plus vitamin D3 supplementation.
  • Forced expiratory volume in 1 second (FEV1) was the primary outcome measure.

Main Results:

  • Both groups demonstrated significant improvement in FEV1 post-intervention.
  • The vitamin D3 intervention group showed a mean FEV1 improvement of 7.07% predicted.
  • The usual care group exhibited a mean FEV1 improvement of 4.95% predicted.

Conclusions:

  • Adjunctive vitamin D3 therapy appears effective in improving lung function in asthma patients.
  • This study provides evidence supporting vitamin D3 as a potential asthma treatment component.
  • Longer-term studies are recommended to substantiate these preliminary findings.
Keywords:
Asthmabudesonideforced expiratory volume in 1 sformoterolvitamin D3

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