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Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
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Asymmetric catalysis with short-chain peptides
Bartosz Lewandowski1, Helma Wennemers1
1Laboratory of Organic Chemistry, ETH Zurich, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland.
Current Opinion in Chemical Biology
|October 4, 2014
Summary
Recent advances in peptide asymmetric catalysis have yielded numerous catalysts for diverse transformations. These peptides offer high stereoselectivity and address key challenges in enantioselective synthesis and reactions in aqueous environments.
Area of Science:
- Organic Chemistry
- Catalysis
- Biochemistry
Background:
- Peptides have emerged as powerful tools in asymmetric catalysis over the past two decades.
- Numerous peptide catalysts have been developed, exhibiting high stereoselectivity and yields across a broad substrate scope.
Purpose of the Study:
- To review recent developments in asymmetric catalysis utilizing peptides.
- To highlight peptide catalysts addressing long-standing challenges in enantioselective synthesis.
Main Methods:
- Review of literature on peptide-based asymmetric catalysis.
- Analysis of catalytic activities and substrate scopes of developed peptides.
Main Results:
- Peptide catalysts demonstrate high stereoselectivity and yields in various organic transformations.
- Successful application of peptides in enantioselective synthesis of atropoisomers and quaternary stereogenic centers.
- Peptides enable regioselective and chemoselective transformations of polyfunctional substrates.
- Advancements in peptide catalysis include in-flow systems and reactions in aqueous media.
Conclusions:
- Peptide-based asymmetric catalysis is a rapidly advancing field with significant potential.
- Peptides offer sustainable and efficient solutions for complex synthetic challenges.
- Future research will likely focus on expanding the scope and efficiency of peptide catalysts.
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