Regeneration in mouse skeletal muscle injured by Trichinella larvae

During the infection caused by Trichinella pseudospiralis serious damage to muscles is partly compensated with regeneration process. Short, thin fibrillae with central position of the nuclei--regenerating myotubes originate 20--40th day post infection in endomysial tubes remaining after damaged muscle fibres, left by migrating larva. On the 10th day post infection in the vicinity of moving larva activation of nuclei and increased origin of satellite cells under basal membrane occur. With development of the infection endothelia in the vicinity of altered fibrillae are increasing in number but there is small inflammatory and fibroproductive reaction only. During the infection caused by Trichinella spiralis and T. nativa, alteration of muscle fibres is accompanied by early inflammatory and fibroproductive reaction towards immediate surroundings of larvae. In a changed segment of muscle fibre with the larva--in pseudocyst there is altered basal lamina as well, built in increased glycocalyx and in the course of 20 days encased by connective tissue. Revascularisation and regeneration in a short damaged segment does not occur even during long-lasting infection because of separation by capsule.