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Updated: Apr 23, 2026

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
Published on: April 19, 2019
Cardiac rehabilitation referral, attendance and mortality in women
Jillian D Colbert1, Billie-Jean Martin2, Mark J Haykowsky3
1Libin Cardiovascular Institute, University of Calgary, Canada.
Insights
Women with coronary artery disease (CAD) benefit significantly from cardiac rehabilitation (CR), experiencing greater mortality reduction than men. Despite lower referral and completion rates, CR participation improves survival for women with CAD.
Area of Science:
- Cardiology
- Public Health
- Health Services Research
Background:
- Cardiac rehabilitation (CR) is proven to reduce mortality in patients with coronary artery disease (CAD).
- Existing research indicates potential sex-based disparities in healthcare utilization and outcomes.
- Understanding these differences is crucial for optimizing cardiovascular disease management.
Purpose of the Study:
- To investigate sex-based differences in long-term mortality among a large cohort of patients with CAD.
- To analyze referral and attendance patterns for CR stratified by sex.
- To determine the impact of CR referral and completion on mortality in women compared to men.
Main Methods:
- Retrospective cohort study utilizing data from the Alberta Provincial Project for Outcomes Assessment in Coronary Heart Disease (APPROACH) and Cardiac Wellness Institute of Calgary (CWIC).
- Comparison of CR referral and attendance rates between men and women.
- Logistic regression to predict CR referral and completion by sex.
- Cox proportional hazard models to assess the association between CR participation and survival, stratified by sex.
Main Results:
- A total of 25,958 patients with CAD were included, with women comprising 24.6%.
- Women had significantly lower rates of CR referral (31.1% vs. 42.2%) and completion (50.1% vs. 60.4%) compared to men.
- After adjusting for covariates, women showed significantly lower odds of CR referral (aOR 0.74) and completion (aOR 0.73).
- Women who completed CR experienced a greater mortality reduction (HR 0.36) than men (HR 0.51), indicating a comparatively greater relative benefit.
Conclusions:
- This large cohort study is the first to demonstrate a significant mortality reduction associated with CR referral and attendance in women with CAD.
- Women derive a comparatively greater survival benefit from participating in CR than men.
- Findings highlight the need to address disparities in CR access and encourage participation among women to improve cardiovascular outcomes.
Background:
Cardiac rehabilitation (CR) reduces mortality in women and men with coronary artery disease (CAD). The objective of this study was to examine sex differences in long-term mortality, based on CR referral rates and attendance patterns in a large CAD population.
Design:
This is a retrospective cohort study.
Methods:
The Alberta Provincial Project for Outcomes Assessment in Coronary Heart Disease (APPROACH) and Cardiac Wellness Institute of Calgary (CWIC) databases were used to obtain information on all patients. Rates of referral to and attendance at CR were compared by sex. Logistic regression models were constructed to assess whether sex predicted CR referral or completion. The association between referral, completion, and survival was assessed by sex using Cox proportional hazard models.
Results:
25,958 subjects (6374-24.6%-were women) with at least one vessel CAD were included. Females experienced reduced rates of CR referral (31.1% vs 42.2%, p < 0.0001) and completion (50.1 vs 60.4%, p < 0.0001). Adjusting for demographic and clinical characteristics, relative to men, CR referral was significantly lower in women (adjusted odds ratio (OR) 0.74, 95% CI 0.69, 0.79) as was CR completion (adjusted OR 0.73, 95% CI 0.66, 0.81). Women completing CR experienced the greatest reduction in mortality (HR 0.36, 95% CI 0.28, 0.45) with a relative benefit greater than men (HR 0.51, 95% CI 0.46, 0.56).
Conclusion:
This is the first large cohort study to demonstrate that referral to and attendance at CR is associated with a significant mortality reduction in women, comparatively better than that in men.
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