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Design, synthesis and exploring the quantitative structure-activity relationship of some antioxidant flavonoid
Sreeparna Das1, Indrani Mitra2, Shaikh Batuta1
1Bio-Organic Chemistry Laboratory, Department of Chemistry, Siksha Bhavana, Visva-Bharati (Central University), Santiniketan 731 235, West Bengal, India.
Abstract:
A series of flavonoid analogues were synthesized and screened for the in vitro antioxidant activity through their ability to quench 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical. The activity of these compounds, measured in comparison to the well-known standard antioxidants (29-32), their precursors (38-42) and other bioactive moieties (38-42) resembling partially the flavone skeleton was analyzed further to develop Quantitative Structure-Activity Relationship (QSAR) models using the Genetic Function Approximation (GFA) technique. Based on the essential structural requirements predicted by the QSAR models, some analogues were designed, synthesized and tested for activity. The predicted and experimental activities of these compounds were well correlated. Flavone analogue 20 was found to be the most potent antioxidant.
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