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Roles of chromatin remodellers in DNA double strand break repair

Penny A Jeggo1, Jessica A Downs1

  • 1Genome Damage and Stability Centre, Life Sciences, University of Sussex, Brighton BN19RQ, UK.

Experimental Cell Research
|October 4, 2014
PubMed

Insights

Chromatin remodelling is crucial for DNA double-strand break (DSB) repair. This review examines how distinct DSB repair pathways utilize chromatin modifications and the role of ATP-driven remodellers in maintaining genomic stability.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • DNA double-strand breaks (DSBs) trigger damage signalling pathways.
  • Understanding DSB repair mechanisms is advancing.
  • The role of chromatin in DSB repair is an emerging focus.

Purpose of the Study:

  • To evaluate the distinct chromatin remodelling requirements of different DSB repair pathways.
  • To review the function of ATP-driven chromatin remodellers in DSB repair.
  • To explore how chromatin modifications influence pathway choice.

Main Methods:

  • Literature review of DSB repair mechanisms.
  • Analysis of chromatin remodelling complex roles in genomic stability.
  • Evaluation of distinct pathway requirements for chromatin modification.

Main Results:

  • Different DSB repair pathways exhibit unique needs for chromatin remodelling.
  • Chromatin modifications play a significant role in regulating DSB repair pathway selection.
  • ATP-driven chromatin remodellers are integral to DSB repair processes.

Conclusions:

  • Chromatin remodelling is essential for efficient DNA double-strand break repair.
  • Understanding these processes is vital, especially given links to cancer via mutations in remodelling complexes.
  • Targeting chromatin remodellers may offer therapeutic strategies for genomic instability.
Keywords:
ChromatinChromatin remodelling complexesDNA damage responsesDNA double strand break repair

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