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Genome Assembly of Methicillin-Resistant Quality Control Strain Staphylococcus aureus CDC73-57501 (ATCC 29247)

H E Daligault1, K W Davenport1, T D Minogue2

  • 1Los Alamos National Laboratory (LANL), Los Alamos, New Mexico, USA.

Genome Announcements
|October 4, 2014
PubMed

Insights

We present the genome assembly for Staphylococcus aureus CDC73-57501, a methicillin-resistant strain. This assembly aids in understanding antibiotic resistance in this common bacterial pathogen.

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Staphylococcus aureus is a significant cause of bacterial infections in the US.
  • High rates of resistance to beta-lactam antibiotics are observed in S. aureus infections.
  • Methicillin-resistant Staphylococcus aureus (MRSA) poses a substantial public health threat.

Purpose of the Study:

  • To provide a high-quality, scaffolded genome assembly for S. aureus CDC73-57501 (ATCC 29247).
  • To establish a genomic resource for a well-characterized methicillin-resistant quality control strain.

Main Methods:

  • Whole-genome sequencing of S. aureus CDC73-57501.
  • Bioinformatic analysis for scaffolded genome assembly.
  • Assembly into 16 contigs.

Main Results:

  • Successful scaffolded genome assembly of S. aureus CDC73-57501 into 16 contigs.
  • The assembly provides a detailed genomic blueprint of this MRSA strain.

Conclusions:

  • The genome assembly of S. aureus CDC73-57501 offers a valuable resource for research.
  • Facilitates further studies into antibiotic resistance mechanisms and development of control strategies.

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