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Related Experiment Video

Updated: Apr 23, 2026

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

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Published on: March 2, 2016

Human astroviruses.

Albert Bosch¹, Rosa M Pintó², Susana Guix²

¹Enteric Virus Laboratory, Department of Microbiology and Institute of Nutrition and Food Safety, University of Barcelona, Barcelona, Spain abosch@ub.edu.

Clinical Microbiology Reviews

|October 4, 2014

Summary

This summary is machine-generated.

Human astroviruses (HAstVs) are diverse RNA viruses causing gastroenteritis in children. Understanding their biology is crucial for preventing zoonotic transmission and future health threats.

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Area of Science:

Virology
Infectious Diseases
Public Health

Background:

Human astroviruses (HAstVs) are positive-sense single-stranded RNA viruses identified in 1975.
The Astroviridae family exhibits high diversity and zoonotic potential, with new astroviruses continually emerging.
Three divergent groups of HAstVs are recognized, with classic HAstVs causing 2-9% of childhood gastroenteritis.

Purpose of the Study:

To review the basic virology, pathogenesis, host response, epidemiology, diagnostic assays, and prevention strategies for HAstVs.
To highlight the need for insights into astrovirus biology due to their zoonotic potential.
To consolidate current knowledge on HAstVs for researchers and public health professionals.

Main Methods:

This review synthesizes information from existing literature on human astroviruses.
It covers aspects from viral biology to clinical and epidemiological data.
Focuses on studies involving cell culture, genetic sequencing, and clinical case reports.

Main Results:

Classic HAstVs have 8 serotypes and are a significant cause of gastroenteritis in children.
While often self-limiting, HAstVs can cause severe disease in immunocompromised individuals.
Emerging astrovirus groups show potential for extraintestinal pathologies and zoonotic transmission.

Conclusions:

The continuous emergence of novel astroviruses necessitates a thorough understanding of their biology.
Insights into HAstV virology and pathogenesis are vital for developing effective prevention strategies.
Addressing the zoonotic potential of astroviruses is key to mitigating future public health risks.