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T-helper heterogeneity and immune response patterns
1DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, Calif.
We have long known that helper T cells regulate antibody-dependent humoral responses; we are now beginning to understand how they do so. In murine systems, there are two TH subsets: One secretes IL-2 and gamma-interferon, the other IL-4 and IL-5. The helper-subset-specific cytokines affect B cells, and therefore the regulation of antibody secretion, in profoundly different ways.
We have long known that helper T cells regulate antibody-dependent humoral responses; we are now beginning to understand how they do so. In murine systems, there are two TH subsets: One secretes IL-2 and gamma-interferon, the other IL-4 and IL-5. The helper-subset-specific cytokines affect B cells, and therefore the regulation of antibody secretion, in profoundly different ways.