Search research articles

Search research articles

Related Experiment Videos

T-helper heterogeneity and immune response patterns.

¹DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, Calif.

Hospital Practice (Office Ed.)

|August 15, 1989

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Two types of mouse helper T-cell clone Implications for immune regulation.

Immunology today·2014

Same author

A novel TLR-9 agonist C792 inhibits plasmacytoid dendritic cell-induced myeloma cell growth and enhance cytotoxicity of bortezomib.

Leukemia·2014

Same author

Allergen-specific T cell responses to immunotherapy monitored by CD154 and intracellular cytokine expression.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2010

Same author

Signalling pathways leading to IFN-alpha production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications.

Journal of internal medicine·2008

Same author

Airway generation-specific differences in the spatial distribution of immune cells and cytokines in allergen-challenged rhesus monkeys.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2005

Same author

Modulation of inhaled antigen-induced IgE tolerance by ongoing Th2 responses in the lung.

Journal of immunology (Baltimore, Md. : 1950)·2001

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Helper T cells regulate antibody production through distinct subsets. These subsets release specific cytokines that differentially impact B cells and antibody secretion, revealing a complex regulatory mechanism.

Area of Science:

Immunology
Cell Biology

Background:

Helper T cells are crucial for adaptive immunity, particularly in orchestrating antibody-dependent humoral responses.
The heterogeneity of helper T cell subsets and their specific roles in B cell regulation are areas of active investigation.

Purpose of the Study:

To elucidate the distinct mechanisms by which different helper T cell subsets regulate antibody production.
To understand the differential impact of subset-specific cytokines on B cell function and antibody secretion.

Main Methods:

Studies were conducted in murine models.
Analysis involved identifying and characterizing distinct helper T cell subsets based on cytokine profiles (e.g., IL-2, gamma-interferon, IL-4, IL-5).
The effects of these cytokines on B cell activity and antibody secretion were assessed.

Related Experiment Videos

Main Results:

Two major helper T cell subsets were identified in murine systems.
One subset secretes Interleukin-2 (IL-2) and gamma-interferon.
The other subset secretes Interleukin-4 (IL-4) and Interleukin-5 (IL-5), demonstrating distinct cytokine profiles.

Conclusions:

Helper T cell subsets exert differential regulatory control over antibody-dependent humoral immunity.
Subset-specific cytokines play a critical role in modulating B cell responses and the quantity/quality of antibody secretion.
Understanding these distinct pathways is key to comprehending humoral immune regulation.