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Practice-Based Knowledge Discovery for Comparative Effectiveness Research: An Organizing Framework.

Robert J Lucero1, Suzanne Bakken2

  • 1Assistant Professor of Nursing Center for Evidence-Based Practice in the Underserved, School of Nursing, Columbia University, New York, New York, United States.

The Canadian Journal of Nursing Research = Revue Canadienne De Recherche En Sciences Infirmieres
|October 4, 2014
PubMed
Summary

This study introduces the Knowledge Discovery through Informatics for Comparative Effectiveness Research (KDI-CER) framework to improve how electronic health data is used for clinical intervention research. It helps organizations discover new knowledge from electronic clinical databases, using hospital-acquired pressure ulcers as an example.

Keywords:
comparative effectivenessdata mininghealth servicesinformaticsknowledge generationresearch

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Area of Science:

  • Health Informatics
  • Outcomes Research
  • Comparative Effectiveness Research

Background:

  • Electronic health information systems offer potential for investigating clinical intervention effects.
  • Current research paradigms may have limitations when analyzing electronic clinical databases.
  • Integrating outcomes and informatics research is crucial for advancing healthcare knowledge.

Purpose of the Study:

  • To present an organizing framework for knowledge discovery in electronic clinical databases.
  • To integrate outcomes and informatics research paradigms.
  • To guide the application of informatics in comparative effectiveness research.

Main Methods:

  • Development of the Knowledge Discovery through Informatics for Comparative Effectiveness Research (KDI-CER) framework.
  • Conceptualizing study designs using a heuristic approach.
  • Illustrating the framework's application with hospital-acquired pressure ulcers (HAPU) data.

Main Results:

  • The KDI-CER framework provides a structured approach to knowledge discovery.
  • It addresses methodological limitations inherent in single-perspective research.
  • Demonstrates the complementary role of informatics in outcomes research.

Conclusions:

  • The KDI-CER framework facilitates knowledge discovery from routinely collected electronic clinical data.
  • It enhances the ability of health-care organizations to conduct comparative effectiveness research.
  • Informatics research advances outcomes research, including CER.