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Effect of High Dose Rosuvastatin Loading before Percutaneous Coronary Intervention on Contrast-Induced Nephropathy

Kyeong Ho Yun1, Jae Hong Lim1, Kyo Bum Hwang1

  • 1Department of Cardiovascular Medicine, Regional Cardiocerebrovascular Center, Wonkwang University Hospital, Iksan, Korea.

Korean Circulation Journal
|October 4, 2014
PubMed

Insights

High-dose rosuvastatin loading before percutaneous coronary intervention (PCI) significantly reduced contrast-induced nephropathy (CIN) in acute coronary syndrome (ACS) patients. This statin pretreatment offers a protective effect against kidney injury post-PCI.

Area of Science:

  • Cardiology
  • Nephrology
  • Pharmacology

Background:

  • Contrast-induced nephropathy (CIN) increases morbidity and mortality in patients undergoing percutaneous coronary intervention (PCI).
  • Identifying effective preventative strategies for CIN is crucial in managing patients with acute coronary syndrome (ACS).

Purpose of the Study:

  • To evaluate the efficacy of high-dose rosuvastatin loading prior to PCI in preventing CIN among ACS patients.
  • To assess the impact of rosuvastatin on renal function markers post-PCI.

Main Methods:

  • An observational study involving 824 ACS patients undergoing PCI.
  • Patients received either 40 mg rosuvastatin loading (statin group, n=408) or no pretreatment (control group, n=416).
  • Serum creatinine and estimated glomerular filtration rate (eGFR) were monitored pre-PCI and up to 48 hours post-PCI.

Main Results:

  • The incidence of CIN was significantly lower in the rosuvastatin group (13.5%) compared to the control group (18.8%), p=0.040.
  • Rosuvastatin loading was independently associated with a decreased risk for CIN (OR, 0.64; 95% CI, 0.43-0.95; p=0.026).
  • Protective effects were more pronounced in subgroups with diabetes, high contrast volume, multivessel disease, elevated CRP, and myocardial infarction.

Conclusions:

  • High-dose rosuvastatin loading before PCI is an effective strategy for reducing CIN incidence in ACS patients.
  • Pre-PCI rosuvastatin administration demonstrates a significant protective effect on renal function following the procedure.
Abstract

Keywords:
Contrast mediaKidneyStatins

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