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Updated: Jul 28, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
Published on: August 6, 2015
A rare case of heterotopic ossification in a newborn: a case report
Ss Khoo1, Lys Felix1, L Azura1
1Department of Orthopaedics and Traumatology, Ampang Hospital, Kuala Lumpur, Malaysia.
Abstract:
Heterotopic ossification (HO) is the growth of bone in soft tissue, and can be broadly classified into neurogenic, genetic and traumatic causes. The pathophysiology of HO remains unknown. This disorder is extremely rare in infants and can mimic or coexist with thrombophlebitis, cellulitis or osteomyelitis. Most importantly, HO has to be differentiated from bone-forming tumours such as osteosarcoma and osteochondroma. We report a case of traumatic HO in a fiveday- old newborn following intravenous cannulation of the right wrist and left ankle, with the latter complicated with osteomyelitis. We highlight the clinical and radiological features of HO and differential diagnoses of soft tissue ossification in early childhood.
Key Words:
Heterotopic ossification, newborn.
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