Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New uses for old drugs.

E Abrutyn1

  • 1Medical College of Pennsylvania, Philadelphia.

Infectious Disease Clinics of North America
|September 1, 1989
PubMed
Summary
This summary is machine-generated.

Older antibiotics show success against new diseases. This review highlights effective uses of common antibiotics like penicillin and vancomycin for emerging or newly recognized illnesses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcomes with daptomycin versus standard therapy for osteoarticular infections associated with Staphylococcus aureus bacteraemia.

The Journal of antimicrobial chemotherapy·2007
Same author

Prosthetic valve endocarditis due to coagulase-negative staphylococci: findings from the International Collaboration on Endocarditis Merged Database.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2006
Same author

Enterococcal prosthetic valve infective endocarditis: report of 45 episodes from the International Collaboration on Endocarditis-merged database.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2005
Same author

Enterococcal endocarditis: 107 cases from the international collaboration on endocarditis merged database.

The American journal of medicine·2005
Same author

Emergence of endocarditis due to group D streptococci: findings derived from the merged database of the International Collaboration on Endocarditis.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2005
Same author

Prognostic factors in 61 cases of Staphylococcus aureus prosthetic valve infective endocarditis from the International Collaboration on Endocarditis merged database.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2004

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pharmacology

Background:

  • New diseases and emerging pathogens necessitate novel therapeutic strategies.
  • Existing antibiotic classes are often overlooked for novel applications.
  • Antimicrobial resistance requires exploring alternative uses for established drugs.

Purpose of the Study:

  • To review the successful repurposing of older, commonly used antibiotics for new or newly recognized diseases.
  • To provide examples of established antimicrobial agents with renewed clinical relevance.

Main Methods:

  • Literature review of clinical applications of established antibiotics.
  • Case study analysis of successful treatment of novel or emerging infections.
  • Synthesis of evidence on the efficacy of older antibiotics against contemporary pathogens.

Related Experiment Videos

Main Results:

  • Demonstrated successful applications of antistaphylococcal agents, penicillin, tetracyclines, erythromycin, vancomycin, trimethoprim-sulfamethoxazole, pyrazinamide, metronidazole, and clindamycin.
  • Identified new uses for these antibiotics in treating "new" or "newly recognized" illnesses.
  • Highlighted the continued effectiveness of these agents against evolving microbial threats.

Conclusions:

  • Established antibiotics remain valuable tools in combating emerging infectious diseases.
  • Repurposing older antibiotics offers a viable strategy for managing novel pathogens.
  • Further research into the expanded applications of existing antimicrobial drugs is warranted.