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Association between LGALS2 3279C>T and coronary artery disease: A case-control study and a meta-analysis

Jiangfang Lian1, Peiliang Fang2, Dongjun Dai3

  • 1Ningbo Medical Center, Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315041, P.R. China.

Biomedical Reports
|October 4, 2014
PubMed

Insights

The LGALS2 3279C>T polymorphism may offer protection against coronary artery disease (CAD), particularly in Asian populations. This finding suggests ethnic variations in the genetic associations with CAD risk.

Area of Science:

  • Genetics
  • Cardiovascular Disease Epidemiology

Background:

  • Coronary artery disease (CAD) is a leading global cause of mortality.
  • The lectin galactoside-binding soluble-2 (LGALS2) gene is implicated in the lymphotoxin-alpha (LTA) cascade, potentially affecting CAD progression.

Purpose of the Study:

  • To investigate the association between the LGALS2 3279C>T (rs7291467) polymorphism and the risk of coronary artery disease (CAD).

Main Methods:

  • A case-control study was conducted with 562 cases and 572 controls.
  • A systematic meta-analysis was performed, including 12,093 cases and 11,020 controls, to evaluate the LGALS2 3279C>T polymorphism's contribution to CAD risk.

Main Results:

  • The case-control study found no significant association between LGALS2 3279C>T and CAD in the Eastern Han Chinese population.
  • The meta-analysis revealed a protective role for the LGALS2 3279C>T polymorphism in CAD (OR, 0.90; 95% CI, 0.82-0.97).
  • This protective effect was more pronounced in the Asian population (OR, 0.82; 95% CI, 0.71-0.94).

Conclusions:

  • The LGALS2 3279C>T polymorphism demonstrates a protective association with coronary artery disease (CAD).
  • Ethnic differences may exist in the relationship between this genetic locus and CAD risk.
  • Further research is warranted to elucidate these ethnic variations.

Keywords:
coronary artery diseaselectin galactoside-binding soluble-2 3279C>Tmeta-analysispolymorphismrs7291467

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