Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Survey Safety01:28

Survey Safety

394
Surveying near highways, rough terrain, or power lines involves significant risks. Working along highways is particularly dangerous and requires the use of warning signs and flagmen. It is safest to avoid working directly on roads and use offsets whenever possible. When highway work is unavoidable, it must follow all safety guidelines. Surveyors should wear bright clothing, such as orange reflective vests, to ensure visibility to motorists, coworkers, and hunters. In construction zones, wearing...
394
Household Wiring And Electrical Safety01:13

Household Wiring And Electrical Safety

1.7K
Companies that supply power to most modern households use three conductors, typically called a three-wire line. While one is neutral, the other two are both at 120 V but with opposite polarity, giving a voltage of 240 V between them. With a three-wire line, high-power appliances that require 240 V, such as electric stoves and clothes dryers, are linked between the two hot lines. 120 V appliances can be connected between the neutral and either of the hot lines. The neutral side, which is always...
1.7K
Labeling Emotion01:20

Labeling Emotion

719
Emotional labeling is a cognitive process that involves identifying and naming one's emotions, such as anger, fear, happiness, or sadness. It allows individuals to recognize and express their internal emotional states, a critical aspect of emotional regulation and communication. Labeling emotions requires more than mere recognition; it also involves drawing upon memory and contextual cues to understand the current situation and apply a corresponding emotional label. For instance, feeling...
719
Labeling DNA Probes03:31

Labeling DNA Probes

9.4K
DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
9.4K
Bystander Effect02:09

Bystander Effect

10.3K
The discussion of bullying highlights the problem of witnesses not intervening to help a victim. This is a common occurrence, as the following well-publicized event demonstrates. In 1964, in Queens, New York, a 19-year-old woman named Kitty Genovese was attacked by a person with a knife near the back entrance to her apartment building and again in the hallway inside her apartment building. When the attack occurred, she screamed for help numerous times and eventually died from her stab wounds.
10.3K
Aggression01:47

Aggression

30.4K
Humans engage in aggression when they seek to cause harm or pain to another person. Aggression takes two forms depending on one’s motives: hostile or instrumental. Hostile aggression is motivated by feelings of anger with intent to cause pain; a fight in a bar with a stranger is an example of hostile aggression. In contrast, instrumental aggression is motivated by achieving a goal and does not necessarily involve intent to cause pain (Berkowitz, 1993); a contract killer who murders for...
30.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Frailty index and risk of pressure injuries in nursing home residents: results from the KASEHPAD cohort.

Scientific reports·2026
Same author

Ageing behind bars: Safeguarding the health and dignity of older people in prison.

Journal of epidemiology and population health·2026
Same author

Daytime impairment and depressive symptoms in patients with obstructive sleep apnea and coexisting insomnia symptoms: A cross-sectional study from a Caribbean sleep center.

Sleep health·2026
Same author

Strengthening healthy ageing in the Caribbean through regional capacity building and ICOPE implementation.

The Journal of frailty & aging·2026
Same author

High prevalence of targetable drivers but poor outcomes in lung adenocarcinoma: a real-world cohort from the French West Indies.

Frontiers in oncology·2026
Same author

The predictive role of feeling lonely in nursing home placement in older adults hospitalized in an emergency setting.

Aging clinical and experimental research·2026
Same journal

In-silico combinatorial design and pharmacophore modeling of potent antimalarial 4-anilinoquinolines utilizing QSAR and computed descriptors.

SpringerPlus·2017
Same journal

Erratum to: Implication of Paris Agreement in the context of long-term climate mitigation goals.

SpringerPlus·2017
Same journal

Erratum to: Associations between adherence, depressive symptoms and health-related quality of life in young adults with cystic fibrosis.

SpringerPlus·2017
Same journal

Erratum to: Numerical method to compute acoustic scattering effect of a moving source.

SpringerPlus·2017
Same journal

Identifying appropriate protected areas for endangered fern species under climate change.

SpringerPlus·2017
Same journal

An Algorithm to detect balancing of iterated line sigraph.

SpringerPlus·2017
See all related articles

Related Experiment Video

Updated: Feb 1, 2026

Simultaneous Label-Free Autofluorescence Multi-Harmonic Microscopy
09:19

Simultaneous Label-Free Autofluorescence Multi-Harmonic Microscopy

Published on: August 29, 2025

611

Methylphenidate off-label use and safety.

Thierry Trenque1, Emmanuelle Herlem2, Malak Abou Taam2

  • 1Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Reims University Hospitals, Avenue du General Koenig, 51092, Reims, France ; Faculty of Medicine, University of Reims Champagne-Ardenne, EA 3797, F-51095 Reims, France.

Springerplus
|October 4, 2014
PubMed
Summary
This summary is machine-generated.

Over 40% of methylphenidate adverse drug reactions involved off-label use, particularly in adults for depression. Further studies are needed to assess the long-term safety of methylphenidate.

Keywords:
MethylphenidateOff-label use

More Related Videos

Prion Safety Laboratory Swipe Test
06:01

Prion Safety Laboratory Swipe Test

Published on: February 14, 2025

1.3K
Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 1. Biosafety Level 4 Suit Laboratory Suite Entry and Exit Procedures
09:54

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 1. Biosafety Level 4 Suit Laboratory Suite Entry and Exit Procedures

Published on: October 3, 2016

37.0K

Related Experiment Videos

Last Updated: Feb 1, 2026

Simultaneous Label-Free Autofluorescence Multi-Harmonic Microscopy
09:19

Simultaneous Label-Free Autofluorescence Multi-Harmonic Microscopy

Published on: August 29, 2025

611
Prion Safety Laboratory Swipe Test
06:01

Prion Safety Laboratory Swipe Test

Published on: February 14, 2025

1.3K
Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 1. Biosafety Level 4 Suit Laboratory Suite Entry and Exit Procedures
09:54

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 1. Biosafety Level 4 Suit Laboratory Suite Entry and Exit Procedures

Published on: October 3, 2016

37.0K

Area of Science:

  • Pharmacovigilance
  • Drug Safety
  • Neuroscience

Background:

  • Methylphenidate, a piperidine derivative, is approved for Attention Deficit Hyperactivity Disorder (ADHD) in children.
  • Its use in adults is not well-defined, except for narcolepsy.
  • The drug received initial regulatory approval nearly sixty years ago.

Purpose of the Study:

  • To investigate the characteristics of off-label methylphenidate use.
  • To analyze spontaneous adverse drug reaction reports associated with methylphenidate.

Main Methods:

  • Analysis of data from the French Pharmacovigilance Database (1985-2011).
  • Evaluation of off-label methylphenidate use based on patient age.
  • Categorization of reported adverse drug reactions.

Main Results:

  • 181 adverse drug reactions (ADRs) reported for methylphenidate.
  • Neuropsychiatric effects were the most common ADRs (41%).
  • Off-label use constituted 43% of all reported cases, with 88% of adult cases being off-label, often for depression, leading to serious events like dependence and suicide attempts.

Conclusions:

  • A significant proportion of methylphenidate-related ADRs stem from off-label indications.
  • Adult off-label use, especially for depression, is associated with severe adverse events.
  • Long-term safety data for methylphenidate requires further investigation through extensive clinical studies.