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Isolation and characterization of (gamma, delta) CD4+ T cell clones derived from human fetal liver cells
P Aparicio1, J M Alonso, M L Toribio
1Centro de Biología Molecular, C.S.I.C., Universidad Autónoma, Madrid, Spain.
The Journal of Experimental Medicine
|September 1, 1989
Abstract:
Lymphocytes isolated from human fetal liver and expanded in vitro in IL-2-containing media reveal the existence of CD4+ gamma, delta T cells. These cells display differential features of double-negative and CD8+ gamma, delta T cells as well as of CD4+ alpha, beta T cells. Thus, they failed to lyse targets in lectin-mediated killing assays and to perform classical helper functions. These results add new information necessary for a better understanding of the physiological role of the gamma, delta T cells.