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Related Experiment Video

Updated: Apr 23, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

Severe primary ocular surface involvement in Behcet disease.

Jun Zeng¹, Baihua Chen

¹*PhD †MD, PhD Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China (both authors).

Optometry and Vision Science : Official Publication of the American Academy of Optometry

|October 4, 2014

Summary

Behcet disease (BD) can cause severe ocular surface inflammation, including corneal ulceration, even without typical uveitis. Early diagnosis and routine eye exams are crucial for managing this rare but serious manifestation.

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Area of Science:

Ophthalmology
Dermatology
Rheumatology

Background:

Behcet disease (BD) is a chronic inflammatory disorder characterized by vasculitis.
Ocular surface involvement is an uncommon anterior segment manifestation of BD.

Observation:

A 26-year-old woman with diagnosed BD presented with severe dry eye, corneal ulceration, and conjunctival lesions.
Confocal microscopy revealed severe bilateral ocular surface inflammation, notably without typical BD ocular signs like uveitis.
Histopathological changes in the eyelid were observed using confocal microscopy.

Findings:

The patient's severe ocular surface disease was a less frequent presentation of Behcet disease.
Histopathological eyelid changes in BD were documented for the first time via confocal microscopy.

Implications:

Ocular surface lesions, even without uveitis, warrant consideration in Behcet disease diagnosis.
Routine ocular surface examination is recommended for BD patients.
Behcet disease should be included in the differential diagnosis for unexplained ocular surface lesions.