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CD147 in cardiovascular disease and thrombosis
Gabrielle J Pennings1, Leonard Kritharides2
1Vascular Biology Group, The ANZAC Research Institute, The University of Sydney, Concord Repatriation General Hospital, New South Wales, Australia.
Seminars in Thrombosis and Hemostasis
|October 4, 2014
Summary
This review highlights CD147's role in thrombosis and inflammation, crucial for coronary artery disease (CAD) development. Understanding CD147 and its binding partners offers insights into arterial disease mechanisms.
Area of Science:
- Cardiovascular Biology
- Immunology
- Molecular Medicine
Background:
- Coronary artery disease (CAD) pathogenesis involves complex thrombotic and inflammatory pathways.
- Extracellular matrix metalloproteinase (CD147) is an immunoglobulin superfamily member expressed on various blood and tissue cells.
- CD147 interacts with diverse binding partners, suggesting multifaceted biological roles.
Purpose of the Study:
- To review the function of CD147 and its binding partners in platelet activation, thrombosis, and arterial disease.
- To explore the mechanistic aspects of CD147 biology relevant to cardiovascular health.
- To consolidate current understanding of CD147's involvement in CAD and cancer.
Main Methods:
- Literature review synthesizing existing research on CD147.
- Analysis of CD147's interactions with known binding partners (e.g., integrins, GPVI, cyclophilins).
- Examination of evidence linking CD147 to thrombotic and inflammatory processes.
Main Results:
- CD147 plays a significant role in platelet function and aggregation.
- Evidence supports CD147's involvement in both inflammatory responses and thrombotic events.
- CD147 is implicated in the development and progression of coronary artery disease.
Conclusions:
- CD147 is a key mediator in thrombosis and inflammation relevant to CAD.
- Further investigation into CD147-binding partner interactions is crucial for understanding arterial disease.
- Targeting CD147 pathways may offer novel therapeutic strategies for cardiovascular diseases.
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