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Updated: Apr 23, 2026
A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
Published on: September 15, 2018
Revisiting the flight of Icarus: making human organs from PSCs with large animal chimeras
Tamir Rashid1, Toshihiro Kobayashi2, Hiromitsu Nakauchi3
1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Centre for Stem Cells and Regenerative Medicine and Institute for Liver Studies, Kings College London, SE1 9RT, UK.
Abstract:
While cell therapies hold great potential for treating many conditions, their utility for treating patients that require whole organ replacement is unclear. To address this challenge, we propose using genetically engineered "organ niches" in large animals to generate human organs from pluripotent stem cells and discuss the hurdles facing such strategies.
