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Related Experiment Video

Updated: Apr 23, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
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Causal pathways between impulsiveness, cocaine use consequences, and depression.

Jamey J Lister1, David M Ledgerwood1, Leslie H Lundahl1

  • 1Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA.

Addictive Behaviors
|October 4, 2014
PubMed
Summary

Cocaine use consequences link trait impulsiveness to depression in regular users. This pathway highlights how impulsivity, through its consequences, contributes to depressive symptoms in this population.

Keywords:
CocaineCocaine use consequencesDepressionImpulsivenessPathways

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Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Neuroscience

Background:

  • Trait impulsiveness is a known risk factor for substance use disorders.
  • Depression is a common comorbidity among individuals with cocaine use disorder.
  • Understanding the interplay between impulsivity, cocaine use, and depression is crucial for effective treatment.

Purpose of the Study:

  • To investigate if lifetime cocaine use consequences mediate the relationship between trait impulsiveness and current depression symptoms.
  • To explore the mediating role of cocaine-related consequences in the impulsivity-depression link.
  • To examine this relationship specifically within a sample of regular cocaine users.

Main Methods:

  • 108 regular cocaine users completed self-report measures.
  • Trait impulsiveness was assessed using Barratt Impulsiveness Scale subscales.
  • Cocaine use consequences and depression symptoms were measured using standardized questionnaires.

Main Results:

  • All impulsiveness subscales correlated positively with earlier cocaine initiation, more depression symptoms, and greater cocaine use consequences.
  • Cocaine use consequences partially mediated the association between each impulsiveness subscale and depression symptoms.
  • No significant moderated mediation was found for the interaction between cocaine use and consequences predicting depression.

Conclusions:

  • Cocaine-related consequences act as a pathway linking trait impulsiveness to depression symptoms.
  • These consequences play a more complex role than merely being an outcome of impulsivity or use.
  • Findings suggest therapeutic targets focusing on managing cocaine use consequences to mitigate depression in impulsive users.