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Updated: Apr 23, 2026

In Vitro Generation of Heart Field-specific Cardiac Progenitor Cells
Published on: July 3, 2019
Genetic networks governing heart development
Ashley J Waardenberg1, Mirana Ramialison2, Romaric Bouveret3
1Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia.
Abstract:
Animal genomes contain a code for construction of the body plan from a fertilized egg. Understanding how genome information is deciphered to create the complex multilayered regulatory systems that drive organismal development, and which become altered in disease, is one of the greatest challenges in the biological sciences. The development of methods that effectively represent and communicate the complexity inherent in gene regulatory networks remains a major barrier. This review introduces the philosophy of systems biology and discusses recent progress in understanding the development of the heart at a systems biology level.
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