Related Experiment Videos
[Available anti-androgens for treating skin hyperandrogenism]
1Hospices Civils de Lyon, Laboratoire de la Clinique Endocrinologique, Hôpital de l'Antiquaille.
Revue Francaise De Gynecologie Et D'Obstetrique
|June 1, 1989
Summary
Cyproterone acetate is a highly effective antiandrogen for treating acne and hirsutism in women, but requires estrogen to prevent amenorrhea. Spironolactone is a well-tolerated alternative for moderate cases, especially in younger patients.
Area of Science:
- Endocrinology
- Dermatology
- Pharmacology
Context:
- Acne and hirsutism in women are common conditions often treated with antiandrogens.
- Several antiandrogen compounds exist, each with varying efficacy and side effect profiles.
Purpose:
- To compare the efficacy and tolerability of cyproterone acetate and spironolactone in treating acne and hirsutism in women.
- To outline optimal prescribing strategies for these antiandrogens, including necessary co-therapies to mitigate side effects.
Summary:
- Cyproterone acetate is the most potent antiandrogen but necessitates concurrent estrogen therapy to prevent amenorrhea.
- Spironolactone is less potent but better tolerated long-term, requiring sequential progestin or norprogesterone to avoid short cycles.
- Combining spironolactone with an estroprogestative lacking nortestosterone offers an easy-to-use, well-tolerated option with good outcomes for acne and hirsutism.
Impact:
- Provides guidance for clinicians on selecting and managing antiandrogen therapy for female patients with acne and hirsutism.
- Highlights the importance of individualized treatment plans considering drug efficacy, tolerability, and potential side effects.
- Offers a well-tolerated therapeutic option for moderate hirsutism or acne in young women.