[Available anti-androgens for treating skin hyperandrogenism]

Several antiandrogens compounds are available in the treatment of acne and hirsutism in women. Cyproterone acetate is the most effective antiandrogen. Its use must prevent the occurrence of amenorrhea with the prescription of an appropriate estrogen. Spironolactone, less effective, is better tolerated on a long-term basis, if precaution is taken to combine it sequentially with a progesterone or a norprogesterone, in order to avoid the occurrence of short cycles. This is the treatment of choice of moderate hirsutism or acne, in young patients. The association of spironolactone with an estroprogestative without nortestosterone is easy to use and well tolerated, and gives good results on acne and hirsutism.