Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypoglycemia01:26

Hypoglycemia

5
Hypoglycemia is a blood glucose level below 70 mg/dL. It commonly occurs in individuals using insulin or insulin-secreting drugs, but may also arise in non-diabetic conditions. People with type 1 diabetes are at the highest risk because they depend on exogenous insulin. People with type 2 diabetes are also at risk, especially when treated with insulin or medications such as sulfonylureas, which increase insulin release regardless of blood glucose levels. It develops when insulin levels exceed...
5
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

1.3K
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
1.3K
Hyperglycemia01:29

Hyperglycemia

2
Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose...
2
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

12
Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the...
12
Hyperosmolar Hyperglycemic State01:21

Hyperosmolar Hyperglycemic State

5
Hyperosmolar Hyperglycemic State, or HHS, is a serious and life-threatening complication of type 2 diabetes mellitus. It is characterized by three main features: severe hyperglycemia, profound dehydration, and elevated serum osmolality, all occurring without significant ketoacidosis.HHS typically develops in older adults or individuals with limited access to fluids. This may result from illness, cognitive impairment, or medications such as diuretics or corticosteroids. These factors reduce...
5
Oral Hypoglycemic Agents: Glinides01:06

Oral Hypoglycemic Agents: Glinides

999
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
999

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<sup>18</sup>F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Guided Stereotactic Body Radiation Therapy in Advanced Breast Cancer Patients Treated WithCyclin-Dependent Kinase 4/6 Inhibitors.

Advances in radiation oncology·2026
Same author

Tableting of nanoparticle-based formulations for oral delivery: Enhancing biopharmaceutical performance.

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences·2026
Same author

Exploratory study of selected stakeholder insights into continuous glucose monitoring in T2D with risk-sharing agreements.

The American journal of managed care·2026
Same author

Oncological outcomes with and without axillary lymph node dissection in patients with residual micrometastases after neoadjuvant chemotherapy (OPBC-07/microNAC): an international, retrospective cohort study.

The Lancet. Oncology·2025
Same author

Clinician Guidance on the Benefits of Healthy Nutrition and Increased Physical Activity for People With Type 2 Diabetes Following Glucagon-Like Peptide 1 Receptor Agonist Initiation.

Clinical diabetes : a publication of the American Diabetes Association·2025
Same author

Management of Atherosclerotic Cardiovascular Disease and Chronic Kidney Disease Risk in People With Type 2 Diabetes: Collaborative Care Plans for Primary Care Physicians Using Effective Communication Styles.

Clinical diabetes : a publication of the American Diabetes Association·2025
Same journal

Mineralocorticoid Antagonists for Post-MI HFpEF: Plausible Biology Meets Low Residual Risk?

The American journal of medicine·2026
Same journal

GLP-1 Receptor Agonists and Age-related Macular Degeneration Risk in Diabetes or Non-diabetic Obesity: A Retrospective Cohort Study.

The American journal of medicine·2026
Same journal

Marijuana Use and Acute Myocardial Infarction: Mechanistic Insights, Clinical Implications, and Emerging Challenges.

The American journal of medicine·2026
Same journal

Cave Canem - Beware of the Dog.

The American journal of medicine·2026
Same journal

Risk Factors for 30-day Hospital Readmission After Hospital-at-Home Treatment of Acute Pyelonephritis.

The American journal of medicine·2026
Same journal

Mesenteric panniculitis.

The American journal of medicine·2026
See all related articles

Related Experiment Video

Updated: Apr 23, 2026

Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique
07:35

Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique

Published on: January 26, 2024

2.1K

Hypoglycemia.

Javier Morales1, Doron Schneider2

  • 1Advanced Internal Medicine Group, P.C., Great Neck, NY.

The American Journal of Medicine
|October 6, 2014
PubMed
Summary
This summary is machine-generated.

Hypoglycemia, a frequent diabetes treatment side effect, hinders glycemic control. Identifying risk factors and patient history is crucial for managing this condition and improving patient outcomes.

Keywords:
Blood glucose managementDiabetesHypoglycemiaInsulin treatmentTreatment options

More Related Videos

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.7K
Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
08:13

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

70.0K

Related Experiment Videos

Last Updated: Apr 23, 2026

Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique
07:35

Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique

Published on: January 26, 2024

2.1K
Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.7K
Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
08:13

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

70.0K

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Diabetes Management

Background:

  • Hypoglycemia is a common, avoidable complication of diabetes treatment.
  • It presents a significant barrier to achieving optimal glycemic control.
  • Understanding risk factors is crucial for effective diabetes management.

Purpose of the Study:

  • To review the incidence, predictors, and consequences of hypoglycemia in diabetes management.
  • To emphasize the importance of accurate patient history in assessing hypoglycemia frequency and severity.
  • To highlight the need for strategies to mitigate hypoglycemia risk.

Main Methods:

  • Literature review and synthesis of existing studies on hypoglycemia in diabetes.
  • Analysis of risk factors, including therapy regimen, patient history, renal insufficiency, age, and autonomic failure.
  • Examination of reported incidence rates and variations due to study design and definitions.

Main Results:

  • Therapy regimen and prior hypoglycemia history are key predictors of future events.
  • Hypoglycemia impacts both type 1 and type 2 diabetes, with varying symptom presentation and diagnosis rates.
  • Severe hypoglycemia is linked to increased mortality, cognitive impairment, and reduced quality of life.

Conclusions:

  • Accurate assessment of hypoglycemia is essential for optimal diabetes care.
  • Reducing hypoglycemia risk through improved self-management and therapy modification is increasingly important.
  • Addressing hypoglycemia is vital for economic reasons, including healthcare costs and workplace productivity.