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Related Concept Videos

Types of Fever01:25

Types of Fever

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Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
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Encephalitis l: Introduction01:19

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Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

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Cytomegalovirus Disease01:27

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Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
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Related Experiment Videos

Multicentric Castleman disease presenting with fever.

Christiana Smith1, Cathy Lee-Miller2, Megan K Dishop3

  • 1Division of Pediatric Infectious Diseases, University of Colorado School of Medicine, Aurora, CO.

The Journal of Pediatrics
|October 6, 2014
PubMed
Summary

Multicentric Castleman disease (MCD) is a rare disorder. Pediatric MCD treatment showed a child improved with chemotherapy after an incomplete response to interleukin-6 therapy.

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Area of Science:

  • Hematology
  • Pediatric Oncology
  • Immunology

Background:

  • Multicentric Castleman disease (MCD) is a rare lymphoproliferative disorder.
  • Symptoms are often nonspecific, including fever and lymphadenopathy.
  • Treatment strategies for pediatric MCD are variable.

Observation:

  • A 21-month-old child presented with fever, leading to an MCD diagnosis.
  • Initial therapy targeting interleukin-6 (IL-6) yielded an incomplete response.
  • Subsequent chemotherapy led to clinical improvement.

Findings:

  • This case highlights the diagnostic challenges of pediatric MCD.
  • It demonstrates a potential treatment pathway for refractory cases.
  • Chemotherapy can be effective when IL-6 targeted therapy is insufficient.

Implications:

  • Further research into optimal pediatric MCD treatment protocols is warranted.
  • Understanding treatment responses can guide future therapeutic decisions.
  • This case contributes to the limited literature on pediatric MCD management.