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Lymphocyte subsets in the cerebrospinal fluid in active multiple sclerosis
R Salonen1, J Ilonen, H Jägerroos
1Department of Neurology, University of Turku, Finland.
Annals of Neurology
|May 1, 1989
Abstract:
We studied the relative number of lymphocyte subsets in the cerebrospinal fluid (CSF) of patients with active multiple sclerosis. The cells were double-labeled with monoclonal antibodies and were studied using a fluorescence-activated cell analyzer. The number of Leu2+Leu15+ cells and Leu3+Leu18+ cells was markedly reduced in the CSF but not in the peripheral blood of the patients. The number of Leu3+Leu18+ cells was reduced also in the CSF of control patients (patients with other inflammatory or infectious neurological diseases).