Effect of methylprednisolone on mammalian neuronal networks in vitro
Matthias Wittstock1, Paulus S Rommer, Florian Schiffmann
1Department of Neurology, University of Rostock, Gehlsheimer Str. 20, 18147, Rostock, Germany, Matthias.wittstock@med.uni-rostock.de.
Abstract:
Glucocorticosteroids (GCS) are widely used for the treatment of neurological diseases, e.g. multiple sclerosis. High levels of GCS are toxic to the central nervous system and can produce adverse effects. The effect of methylprednisolone (MP) on mammalian neuronal networks was studied in vitro. We demonstrate a dose-dependent excitatory effect of MP on cultured neuronal networks, followed by a shut-down of electrical activity using the microelectrode array technique.
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