²⁰¹Tl⁺-labelled Prussian blue nanoparticles as contrast agents for SPECT scintigraphy.

Area of Science:

• Nanochemistry
• Radiochemistry
• Molecular Imaging

Background:

• Prussian blue (PB) nanoparticles are versatile nano-objects.
• PB combines properties of molecular materials and nanochemistry.
• Nanoscale PB offers unique advantages for biomedical applications.

Purpose of the Study:

• To develop novel nanoprobes for medical imaging.
• To utilize ultra-small Prussian blue nanoparticles.
• To create radiotracers for 201-thallium imaging.

Main Methods:

• Synthesis of ultra-small Prussian blue nanoparticles (2-3 nm).
• Labeling of nanoparticles with radioactive 201Thallium (201Tl+).
• Characterization of the resulting nanoprobes.

Main Results:

• Successfully synthesized 2-3 nm Prussian blue nanoparticles.
• Achieved efficient radiolabeling with 201Tl+.
• Developed new nanoprobes suitable for radiotracer applications.

Conclusions:

• Ultra-small PB nanoparticles are excellent platforms for radiotracer development.
• The new 201Tl+-labeled PB nanoprobes show promise for 201-thallium-based imaging.
• This work advances the field of molecular imaging with novel nanomaterials.