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Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
Effect of a common genetic variant microRNA-146a rs2910164 on colorectal cancer: a meta-analysis
Wen Qun Xie1, Shi Yun Tan, Xiao Fan Wang
1Key Laboratory of Digestive Disease, Department of Digestive Disease, Renmin Hospital of Wuhan University, Wuhan, China.
Objective:
There is emerging evidence that the microRNA-146a (miR-146a) rs2910164 polymorphism might be associated with the susceptibility to colorectal cancer (CRC). However, previous published studies have failed to achieve a definitive conclusion. We aimed to address this issue in an updated meta-analysis.
Methods:
A comprehensive literature search was conducted in PubMed, Embase, China BioMedicine, the Cochrane Library and Google Scholar to identify eligible studies. Case-control studies written in English that evaluated the association between miR-146a polymorphism and CRC were included. Odds ratio and 95% confidence interval were calculated in the quantitative synthesis.
Results:
Overall seven case-control studies including a total of 2978 cases and 3576 cancer-free or healthy controls were enrolled in the meta-analysis. The results indicated that there was no association between miR-146a G/C rs2910164 polymorphism and CRC risk either in the overall analysis or among Asians, when stratified on the basis of ethnicity.
Conclusion:
miR-146a G/C genetic polymorphism was not related to the susceptibility to CRC.
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