Related Experiment Video
Updated: Apr 23, 2026
08:20
In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
Published on: December 30, 2016
20.0K
Target tissue ectoenzyme CD39/CD73-expressing Foxp3+ regulatory T cells in patients with psoriasis
1Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China; Bethune International Peace Hospital, Shijiazhuang, China.
Clinical and Experimental Dermatology
|October 7, 2014
Summary
Regulatory T cells (Tregs) use CD39 and CD73 ectoenzymes to suppress immune responses. Psoriatic lesions show reduced CD39/CD73 expression on Tregs, suggesting different disease mechanisms in psoriasis vulgaris versus pustular or erythrodermic psoriasis.
Area of Science:
- Immunodermatology
- T-cell immunology
- Psoriasis pathogenesis
Background:
- Psoriasis is a chronic inflammatory skin disease.
- Regulatory T cells (Tregs) are crucial in psoriasis.
- Treg ectoenzymes CD39 and CD73 modulate Treg suppressive activity.
Purpose of the Study:
- To quantify CD39 and CD73 expression on Foxp3(+) Tregs in various psoriatic lesions.
- To compare Treg ectoenzyme expression across different psoriasis types.
Main Methods:
- Immunohistochemical staining of Foxp3, CD39, and CD73.
- Analysis of biopsy tissues from healthy controls and psoriasis patients.
- Quantitative assessment of co-expressing cells.
Main Results:
- CD39(+) and Foxp3(+) cells were significantly lower in pustular psoriasis (PP) and erythrodermic psoriasis (EP) compared to psoriasis vulgaris (PV).
- CD73(+) and Foxp3(+) cells were also significantly reduced in PP and EP versus PV.
- No significant difference in double-positive cell populations between PP and EP.
Conclusions:
- Reduced CD39 and CD73 expression on Foxp3(+) Tregs in specific psoriatic lesions.
- Suggests distinct immunopathogenesis for different types of psoriasis.
- Highlights the role of Treg ectoenzymes in psoriasis heterogeneity.
