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Updated: Apr 23, 2026

Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples
Published on: December 22, 2014
Metabolomics technology and their application to the study of the viral infection
Antonio Noto1, Angelica Dessi, Melania Puddu
1Department of Surgery, NICU, Puericulture Institute and Neonatal Section, AOU, University of Cagliari, Cagliari , Italy and.
Objective:
In the present review article we have summarized the use of the metabolomics approach to study the metabolic modifications occurring in several bio-fluids due to viral infections. The aim is to highlight the ability of metabolomics to find early fingerprints, which are related to the infections.
Methods:
The (1)H-NMR, UHPLC/MS/MS(2), UPLC/ESI-SYNAPT-HDMS, UPLC-Q-TOF-HDMS analyses were used for the determination of several metabolites representative of the viral infections. The data were analyzed by Principal Component Analysis (PCA), Partial Least Square Discriminant Analysis (PLS-DA) and by regression techniques.
Results:
The major changes were related to nucleotide, carbohydrates, lipids and amino acid metabolisms.
Conclusions:
The metabolomics approach could be considered a viable option for characterization of the viral infection and for detecting on going differences in the bio-fluids composition.
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