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Related Concept Videos

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

343
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
343
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

200
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
200
Hypersensitivities01:30

Hypersensitivities

7.1K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.1K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

247
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
247
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

267
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
267

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Related Experiment Video

Updated: Apr 23, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
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Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

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Delayed-type hypersensitivity reaction against Nexplanon®.

Maurizio Serati1, Giorgio Bogani1, Sanjeev Kumar2

  • 1Department of Obstetrics and Gynecology, University of Insubria, Varese, Italy.

Contraception
|October 7, 2014
PubMed
Summary
This summary is machine-generated.

Nexplanon, a long-acting contraceptive implant, is generally safe but can rarely cause adverse events. This case report details a delayed-type hypersensitivity reaction to the etonogestrel implant that resolved upon removal.

Keywords:
Adverse eventAllergyContraceptiveDelayed-type hypersensitivity reactionNexplanon®

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Area of Science:

  • Reproductive Medicine
  • Pharmacovigilance
  • Dermatology

Background:

  • Nexplanon® is a widely used etonogestrel implant providing long-acting contraception.
  • While generally safe, rare adverse events associated with contraceptive implants necessitate ongoing monitoring.

Observation:

  • A case of delayed-type hypersensitivity reaction to the Nexplanon® implant is presented.
  • The patient experienced moderate to severe adverse effects attributed to the etonogestrel implant.

Findings:

  • The hypersensitivity reaction resolved completely after the Nexplanon® implant was surgically removed.
  • This case highlights a rare but significant adverse event potentially linked to etonogestrel implants.

Implications:

  • Clinicians should consider hypersensitivity reactions in patients presenting with unexplained adverse events post-implant insertion.
  • Prompt diagnosis and removal of the etonogestrel implant can effectively manage such rare allergic responses.