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Plasminogen polymorphism in swine.

J Rapacz1, Z Reiner, S Q Ye

  • 1Lipoprotein and Atherosclerosis Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104.

Comparative Biochemistry and Physiology. B, Comparative Biochemistry
|January 1, 1989
PubMed
Summary
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Swine plasminogen polymorphism was identified, revealing eleven patterns including a null type. This null pattern correlated with altered lipid levels and changes after nursing.

Area of Science:

  • Animal Genetics
  • Biochemistry

Background:

  • Plasminogen is a key protein in the fibrinolytic system.
  • Understanding genetic variations in plasminogen is important for animal health and physiology.

Purpose of the Study:

  • To investigate plasminogen polymorphism in swine (Sus scrofa).
  • To characterize the phenotypic patterns of plasminogen in swine plasma.
  • To explore potential associations of plasminogen patterns with physiological parameters.

Main Methods:

  • Immunoblotting techniques were employed to detect plasminogen variants in swine plasma.
  • Phenotypic classification of detected plasminogen patterns was performed.

Main Results:

  • Eleven distinct plasminogen phenotypic patterns were identified in swine, including a rare null pattern.

Related Experiment Videos

  • The null plasminogen pattern was significantly associated with markedly reduced plasma triglyceride concentrations.
  • Increased unesterified cholesterol levels were observed in conjunction with the null plasminogen pattern.
  • Developmental changes in plasminogen polymorphic patterns were noted from fetal to neonatal stages post-nursing.

    • Conclusions:

    • Swine exhibit significant plasminogen polymorphism.
    • The null plasminogen phenotype is linked to specific alterations in lipid metabolism.
    • Postnatal physiological changes, such as nursing, influence plasminogen expression patterns in developing swine.