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Salvadenosine, a 5'-deoxy-5'-(methylthio) nucleoside from the Bahamian tunicate Didemnum sp
Matthew T Jamison1, Christopher N Boddy, Tadeusz F Molinski
1Department of Chemistry and Biochemistry and Skaggs School of Pharmacy and §Department of Pharmaceutical Sciences, University of California, San Diego , La Jolla, California 92093-0358, United States.
Abstract:
Salvadenosine, (1) a rare 5'-deoxy-5'-(methylthio) nucleoside, was isolated from the deep-water Bahaman tunicate Didemnum sp. The structure was solved by integrated analysis of MS and 1D and 2D NMR data. We revise the structure of the known natural product, hamiguanosinol, which is a constitutional isomer of 1, to 5 by interpretation of the spectroscopic data and comparison with synthesized nucleosides.
