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Translationally-Relevant Tumor Resection Model for Murine Preclinical Models of Oral Squamous Cell Carcinoma
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Oral cavity squamous cell carcinoma--an overview.

Adam J Kimple1, Chris M Welch, Jose P Zevallos

  • 1Department of Otolaryngology-Head and Neck Surgery, University of North Carolina Memorial Hospitals, 170 Manning Dr., Ground Floor Physician Office Building, CB#7070, Chapel Hill, NC 27599, USA; Tel: 919-966-6484; Fax: 919-966-7941;

Oral Health and Dental Management
|October 7, 2014
PubMed
Summary

Tobacco use, alcohol, and betel nut quid are major risk factors for oral cavity squamous cell carcinoma. Early detection during dental visits is crucial for managing this preventable cancer.

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Area of Science:

  • Oncology
  • Dental Medicine
  • Public Health

Background:

  • Tobacco use (inhaled or chewed) is addictive, harmful, and affects over 1 billion daily users worldwide.
  • Tobacco is the primary preventable cause of oral cavity squamous cell carcinoma (OSCC).
  • Alcohol and betel nut quid consumption also significantly contribute to the OSCC burden.

Purpose of the Study:

  • To review the anatomy, epidemiology, pathogenesis, evaluation, and treatment of oral cavity squamous cell carcinoma.
  • To emphasize the role of dental visits in identifying early oral lesions.

Main Methods:

  • This is a review article.
  • It synthesizes current knowledge on OSCC.

Main Results:

  • Oral cavity squamous cell carcinoma is linked to tobacco, alcohol, and betel nut quid.
  • Dental professionals are well-positioned for early lesion detection.

Conclusions:

  • Understanding OSCC's multifaceted etiology is key.
  • Early identification and intervention are critical for improving patient outcomes.