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Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration
Published on: May 26, 2014
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Oxygen supersaturated fluid using fine micro/nanobubbles
Noriaki Matsuki1, Takuji Ishikawa2, Shingo Ichiba3
1Department of Biomedical Engineering, Graduate School of Engineering, Okayama University of Science, Okayama, Japan.
International Journal of Nanomedicine
|October 7, 2014
Summary
Oxygen micro/nanobubbles (OFM-NBs) create oxygen-supersaturated fluids for improved blood oxygenation. Normal saline is ideal for infusion, while dextran aids drug delivery, offering potential in treating hypoxia and other conditions.
Area of Science:
- Biomedical Engineering
- Materials Science
- Medical Fluidics
Background:
- Microbubbles exhibit unique properties like gas solubility and free radical production.
- Oxygen microbubble fluid offers potential for oxygen delivery to hypoxic tissues.
- Comparative studies on oxygen fine micro/nanobubbles (OFM-NBs) in common infusion solutions are lacking.
Purpose of the Study:
- To investigate the generation of oxygen-supersaturated fluids using OFM-NBs.
- To assess the safety and efficacy of OFM-NBs in common infusion solutions for intravenous administration.
- To evaluate the potential of OFM-NBs for improving blood oxygenation.
Main Methods:
- Generation of oxygen-supersaturated fluids using OFM-NBs in normal saline and dextran solutions.
- Assessment of OFM-NB size for safe intravenous infusion.
- Evaluation of blood oxygenation improvement using normal saline with OFM-NBs.
Main Results:
- OFM-NBs successfully generated oxygen-supersaturated fluids.
- Normal saline was identified as preferable for a 30-minute oxygen-rich infusion.
- Dextran solution proved suitable for 1-hour drug delivery with oxygen gas.
- Normal saline containing OFM-NBs effectively improved blood oxygenation.
Conclusions:
- OFM-NBs can create safe, oxygen-supersaturated infusion fluids.
- Normal saline and dextran solutions are viable carriers for OFM-NBs with specific administration protocols.
- OFM-NB-containing fluids represent a novel approach for enhancing blood oxygenation in various medical conditions.
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