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Updated: Apr 23, 2026

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration

Published on: May 26, 2014

Oxygen supersaturated fluid using fine micro/nanobubbles.

Noriaki Matsuki¹, Takuji Ishikawa², Shingo Ichiba³

¹Department of Biomedical Engineering, Graduate School of Engineering, Okayama University of Science, Okayama, Japan.

International Journal of Nanomedicine

|October 7, 2014

Summary

Oxygen micro/nanobubbles (OFM-NBs) create oxygen-supersaturated fluids for improved blood oxygenation. Normal saline is ideal for infusion, while dextran aids drug delivery, offering potential in treating hypoxia and other conditions.

Keywords:

fine micro/nanobubble fluid oxygenation microbubble nanobubble oxygenation

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Area of Science:

Biomedical Engineering
Materials Science
Medical Fluidics

Background:

Microbubbles exhibit unique properties like gas solubility and free radical production.
Oxygen microbubble fluid offers potential for oxygen delivery to hypoxic tissues.
Comparative studies on oxygen fine micro/nanobubbles (OFM-NBs) in common infusion solutions are lacking.

Purpose of the Study:

To investigate the generation of oxygen-supersaturated fluids using OFM-NBs.
To assess the safety and efficacy of OFM-NBs in common infusion solutions for intravenous administration.
To evaluate the potential of OFM-NBs for improving blood oxygenation.

Main Methods:

Generation of oxygen-supersaturated fluids using OFM-NBs in normal saline and dextran solutions.
Assessment of OFM-NB size for safe intravenous infusion.
Evaluation of blood oxygenation improvement using normal saline with OFM-NBs.

Main Results:

OFM-NBs successfully generated oxygen-supersaturated fluids.
Normal saline was identified as preferable for a 30-minute oxygen-rich infusion.
Dextran solution proved suitable for 1-hour drug delivery with oxygen gas.
Normal saline containing OFM-NBs effectively improved blood oxygenation.

Conclusions:

OFM-NBs can create safe, oxygen-supersaturated infusion fluids.
Normal saline and dextran solutions are viable carriers for OFM-NBs with specific administration protocols.
OFM-NB-containing fluids represent a novel approach for enhancing blood oxygenation in various medical conditions.